On December 20, the research team led by Professors Jin Shengwei, Professors Li Ting, and Professors Gao Fang of the Department of Anesthesiology at WMU published their research results in the top international clinical medical journal JAMA (The Journal of the American Medical Association, IF= 56.27), clarifying the effect of different anesthesia methods on postoperative brain function of elderly patients. The editorial comment in the same issue concluded that the study has changed the traditional idea that "general anesthesia can cause brain dysfunction in elderly patients" and provided important guidance for clinical practice. Affiliation for the first author and the corresponding author of the paper is the Second Affiliated Hospital of Wenzhou Medical University.
According to statistics, there are currently 727 million people over the age of 65 globally, including 190 million in China. The proportion of elderly patients undergoing surgery in China accounts for 30% of all surgical patients, and the proportion of patients aged over 65 years old in the United States accounts for up to 50% of all surgical patients. Due to the decline of organ function and the decrease of physiological reserve, the choice of anesthesia methods and management for elderly patients has always been the focus of debate in the medical field. Conventionally, most doctors prefer to use regional anesthesia, considering general anesthesia would affect the brain function of elderly patients. However, the physical and psychological stress such as fear and pain caused by regional anesthesia can have a serious impact on the patient's recovery.
WMU’s anesthesiology team has adopted a multi-center, randomized controlled trial design and set strict criteria for the selection and exclusion of subjects since 2014. It took 5 years to complete the clinical screening and data collection of 2229 subjects, and finally 950 subjects were enrolled. The study confirmed that there was no difference in the effects of regional anesthesia and general anesthesia on the incidence, types, or severity of postoperative delirium in elderly patients undergoing fragility hip fracture repair. This finding will inform the choice of anesthesia methods and have a profound impact on the management of anesthesia for elderly patients.
In recent years, under the leadership of Professor Jin Shengwei, the department of anesthesiology at WMU has continuously strengthened its connotation construction. It ranked seventh nationally in 2019 and eighth in 2020 in the rankings of anesthesiology discipline according to the Science and Technology Evaluation Metrics (STEM) Rankings of Chinese Hospitals, which is one of the two disciplines of WMU that has entered the national top ten. In recent years, the department of anesthesiology has undertaken more than 20 national-level projects including national key projects, national major research plan cultivation projects, and major new drug creation key projects of the Ministry of Science and Technology. It has won more than 10 awards including the First Prize of the Zhejiang Provincial Science and Technology Progress Award, and was approved as the national clinical trial base for anesthesia drugs, the national-level first-class undergraduate program construction site, provincial key laboratory, the first-class discipline of the province's top priority, etc. The publication of this paper is one of the landmark achievements of years of construction of the anesthesiology discipline.
Founded in 1883, JAMA is known as one of the world's top three comprehensive medical journals, together with NEJM (New England Journal of Medicine) and Lancet (The Lancet), and consistently reports the most important breakthroughs in the global medical field.
Text translated by MiaoYu and reviewed by Sun You.